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Submit ReviewBIM 23042
说明： Selective neuromedin B receptor antagonist (NMB-R, BB1)
生物活性 for BIM 23042
BIM 23042 is a selective neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 216 and 18,264 nM for BB1 and BB2 receptors respectively). Displays no activity at a range of other receptors.
技术数据 for BIM 23042
| 分子量 | 1192.46 |
| 公式 | C63H73N11O9S2 |
| 序列 |
XCYWKVCX (Modifications: Disulfide bridge between 2 - 7, X-1 = D-Nal, Trp-4 = D-Trp, X-8 = Nal & C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 111857-96-6 |
| PubChem ID | 16173213 |
| InChI Key | WASLGBPOQJKRMS-AAFDAGAGSA-N |
| Smiles | [H]N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BIM 23042
参考文献 for BIM 23042
参考文献是支持产品生物活性的出版物。
Orbuch et al (1993) Discovery of a novel class of neuromedin B receptor antagonists, substituted somatostatin analogues. Mol.Pharmacol. 44 841 PMID: 7901752
Ryan et al (1996) Pharmacological profiles of two bombesin analogues in cells transfected with human neuromedin B receptors. Eur.J.Pharmacol. 306 307 PMID: 8813645
Milusheva et al (1998) Role of different bombesin receptor subtypes mediating contractile activity in cat upper gastrointestinal tract. Peptides 19 549 PMID: 9533644
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关键词: BIM 23042, BIM 23042 supplier, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, BIM23042, Receptors, 3237, Tocris Bioscience
1 篇 BIM 23042 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BIM 23042 的部分引用包括：
Blais et al (2016) Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin Neuroscience Letters 633 262 PMID: 27693662
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.