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BIRT 377

Cat. No. 4776 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent negative allosteric modulator of LFA-1
化学名： (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BIRT 377

BIRT 377 is a potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). BIRT 377 binds to the I-domain of LFA-1. BIRT 377 reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. BIRT 377 inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.

技术数据 for BIRT 377

分子量 442.13
公式 C18H15BrCl2N2O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 213211-10-0
PubChem ID 9803375
InChI Key FJNJHZQMQRVZEE-GOSISDBHSA-N
Smiles CN([C@@](CC3=CC=C(Br)C=C3)(C)C(N1C2=CC(Cl)=CC(Cl)=C2)=O)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BIRT 377

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.21 100
ethanol 8.84 20

制备储备液 for BIRT 377

以下数据基于产品分子量 442.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.31 mL 22.62 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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产品说明书 for BIRT 377

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for BIRT 377

参考文献是支持产品生物活性的出版物。

Kelly et al (1999) Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J.Immunol. 163 5173 PMID: 10553036

Wu et al (2004) Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives. J.Med.Chem. 47 5356 PMID: 15481974

Last-Barney et al (2001) Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction. J.Am.Chem.Soc. 123 5643 PMID: 11403595

If you know of a relevant reference for BIRT 377, please let us know.

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关键词: BIRT 377, BIRT 377 supplier, BIRT377, potent, negative, allosteric, modulators, LFA-1, lymphocyte, function-associated, antigen-1, cell, adhesion, orally, available, integrins, NAM, Integrins, Cell, Adhesion, Molecules, 4776, Tocris Bioscience

4 篇 BIRT 377 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIRT 377 的部分引用包括：

Mancuso et al (2020) Anti-aLβ2 antibodies reveal novel endocytotic cross-modulatory functionality. Br.J.Pharmacol. 177 2696 PMID: 31985813

Noor et al (2019) LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes. Neuroimmunol Neuroinflammation 6 11 PMID: 31763376

Yu et al (2022) C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models. Cancer Immunol Res 10 245-258 PMID: 34819308

Erin D et al (2020) The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions. Brain Behav Immun 87 339-358 PMID: 31918004

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