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BIX NHE1 inhibitor

Cat. No. 5512 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective NHE1 inhibitor
化学名： 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BIX NHE1 inhibitor

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

技术数据 for BIX NHE1 inhibitor

分子量 392.8
公式 C16H19F3N4O2.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1422252-46-7
PubChem ID 121513866
InChI Key SLSZLEROFKLICF-UHFFFAOYSA-N
Smiles CC(N(CC2)CCC2C1=C(C(F)(F)F)C=C(C(NC(N)=N)=O)C=C1)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BIX NHE1 inhibitor

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 19.64 50

制备储备液 for BIX NHE1 inhibitor

以下数据基于产品分子量 392.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.09 mL 25.46 mL 50.92 mL
2.5 mM 1.02 mL 5.09 mL 10.18 mL
5 mM 0.51 mL 2.55 mL 5.09 mL
25 mM 0.1 mL 0.51 mL 1.02 mL

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产品说明书 for BIX NHE1 inhibitor

分析证书/产品说明书
化学品安全技术说明书

参考文献 for BIX NHE1 inhibitor

参考文献是支持产品生物活性的出版物。

Kilić et al (2014) Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation. J.Pharmacol.Exp.Ther. 351 492 PMID: 25216745

Huber et al (2012) Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J.Med.Chem. 55 7114 PMID: 22803959

If you know of a relevant reference for BIX NHE1 inhibitor, please let us know.

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关键词: BIX NHE1 inhibitor, BIX NHE1 inhibitor supplier, BIXNHE1, inhibitor, sodium, hydrogen, exchanger, isoform1, inhibitors, inhibits, potent, selective, hypertrophy, ischemia, Na+/H+, Exchanger, 5512, Tocris Bioscience

1 篇 BIX NHE1 inhibitor 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIX NHE1 inhibitor 的部分引用包括：

Valerie M et al (2021) Adhesion-mediated mechanosignaling forces mitohormesis. Cell Metab 33 1322-1341.e13 PMID: 34019840

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