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BMH 21

Cat. No. 5417 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： RNA polymerase I inhibitor; also p53 pathway activator
化学名： N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMH 21

BMH 21 is a p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

技术数据 for BMH 21

分子量 360.41
公式 C21H20N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 896705-16-1
PubChem ID 3508054
InChI Key BXYDVWIAGDJBEC-UHFFFAOYSA-N
Smiles O=C2N4C(C(C(NCCN(C)C)=O)=CC=C4)=NC(C2=C3)=CC1=C3C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMH 21

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1.8 5 温和加热

制备储备液 for BMH 21

以下数据基于产品分子量 360.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 55.49 mL 277.46 mL 554.92 mL
0.25 mM 11.1 mL 55.49 mL 110.98 mL
0.5 mM 5.55 mL 27.75 mL 55.49 mL
2.5 mM 1.11 mL 5.55 mL 11.1 mL

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参考文献 for BMH 21

参考文献是支持产品生物活性的出版物。

Peltonen et al (2014) A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 13 77 PMID: 24434211

Colis et al (2014) Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 57 4950 PMID: 24847734

Peltonen et al (2010) Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 5 e12996 PMID: 20885994

If you know of a relevant reference for BMH 21, please let us know.

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关键词: BMH 21, BMH 21 supplier, BMH21, p53, pathway, activators, rna, polymerase, inhibitors, inhibits, RPA194, antitumor, DNA,, RNA, and, Protein, Synthesis, Polymerase, 5417, Tocris Bioscience

1 篇 BMH 21 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMH 21 的部分引用包括：

McCullough et al (2018) Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Transl Psychiatry 8 164 PMID: 30135420

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