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BMS 265246

Cat. No. 5654 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cdk inhibitor; potently inhibits cdk1 and cdk2
化学名： (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone
纯度： ≥97% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMS 265246

BMS 265246 is a potent cyclin-dependent kinase 1 (cdk1) and cdk 2 inhibitor (IC50 values are 5.6 - 71 and 6 - 14 nM, respectively). Also inhibits cdk4 and cdk5 in the sub micromolar range and cdk7 and cdk9 in the low micromolar range. Inhibits proliferation of HCT-116 colon cancer cells in vitro.

External Portal Information for BMS 265246

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMS-265246 is reviewed on the chemical probes website.

化合物库 for BMS 265246

BMS 265246 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BMS 265246

分子量 345.34
公式 C18H17F2N3O2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 582315-72-8
PubChem ID 5329775
InChI Key SCFMWQIQBVZOQR-UHFFFAOYSA-N
Smiles CCCCOC1=C2C=NNC2=NC=C1C(C3=C(C=C(C=C3F)C)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMS 265246

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.27 50

制备储备液 for BMS 265246

以下数据基于产品分子量 345.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.79 mL 28.96 mL 57.91 mL
2.5 mM 1.16 mL 5.79 mL 11.58 mL
5 mM 0.58 mL 2.9 mL 5.79 mL
25 mM 0.12 mL 0.58 mL 1.16 mL

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参考文献 for BMS 265246

参考文献是支持产品生物活性的出版物。

Misra et al (2003) 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg.Med.Chem.Lett. 13 2405 PMID: 12824044

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for BMS 265246, please let us know.

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关键词: BMS 265246, BMS 265246 supplier, BMS265246, potent, cyclin, dependent, kinases, cdk1, cdk2, inhibitors, inhibits, Cyclin-dependent, Kinase, Non-selective, CDKs, 5654, Tocris Bioscience

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