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BMS 309403

Cat. No. 5258 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective FABP4 inhibitor
化学名： 2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMS 309403

BMS 309403 is a potent and selective fatty acid binding protein 4, adipocyte (FABP4) inhibitor (Ki values are <2, 250 and 350 nM for FABP4, FABP3 and FABP5 respectively). Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity. Orally active.

化合物库 for BMS 309403

BMS 309403 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BMS 309403

分子量 474.55
公式 C31H26N2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 300657-03-8
PubChem ID 16122583
InChI Key SJRVJRYZAQYCEE-UHFFFAOYSA-N
Smiles CCC1=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=NN1C2=CC=CC=C2C3=CC=CC(OCC(O)=O)=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMS 309403

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.45 100

制备储备液 for BMS 309403

以下数据基于产品分子量 474.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.07 mL
5 mM 0.42 mL 2.11 mL 4.21 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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产品说明书 for BMS 309403

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for BMS 309403

参考文献是支持产品生物活性的出版物。

Furuhashi et al (2007) Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447 959 PMID: 17554340

Sulsky et al (2007) Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg.Med.Chem.Lett. 17 3511 PMID: 17502136

Lin et al (2012) BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase. PLoS ONE 7 e44570 PMID: 22952994

If you know of a relevant reference for BMS 309403, please let us know.

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关键词: BMS 309403, BMS 309403 supplier, BMS309403, potent, selective, fatty, acid, binding, protein, adipocyte, aFABP4, inhibitors, inhibits, insulin, sensitivity, atherosclerosis, FABP4, Fatty, Acid, Binding, Proteins, 5258, Tocris Bioscience

2 篇 BMS 309403 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMS 309403 的部分引用包括：

M et al (2021) Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence. Nat Commun 12 5507 PMID: 34535653

Renate et al (2022) Pharmacological Inhibition of Lipid Import and Transport Proteins in Ovarian Cancer. Cancers (Basel) 14 PMID: 36497485

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