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BMS 466442

Cat. No. 6878 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective inhibitor of asc-1
化学名： N-[[5-Methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-L-histidine methyl ester
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMS 466442

BMS 466442 is a potent and selective asc-1 (alanine-serine-cysteine-1) transporter inhibitor (IC50 values are 20 and 37 nM in rat primary cortical cultures and HEK cells expressing asc-1 respectively). Displays >1000-fold selectivity for asc-1 over LAT-2 and ASCT-2. This compound is unsuitable for in vivo studies.

技术数据 for BMS 466442

分子量 538.6
公式 C31H30N4O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1598424-76-0
PubChem ID 124082063
InChI Key UUCAHZCMRZOTNF-MHZLTWQESA-N
Smiles COC(=O)[C@H](CC1=CN(CC2=CC=CC=C2)C=N1)NC(=O)C1=CC2=CC(OC)=C(OCC3=CC=CC=C3)C=C2N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMS 466442

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 53.86 100

制备储备液 for BMS 466442

以下数据基于产品分子量 538.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.28 mL 18.57 mL
5 mM 0.37 mL 1.86 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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参考文献 for BMS 466442

参考文献是支持产品生物活性的出版物。

Torrecillas et al (2019) Inhibition of the alanine-serine-cysteine-1 transporter by BMS-466442. ACS Chem.Neurosci. 10 2510 PMID: 30821959

Brown et al (2014) In vitro characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J.Neurochem. 129 275 PMID: 24266811

If you know of a relevant reference for BMS 466442, please let us know.

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关键词: BMS 466442, BMS 466442 supplier, BMS466442, potent, selective, asc-1, alanine-serine-cysteine-1, transporters, inhibitors, inhibits, SLC7A10, Other, Ion, Pumps/Transporters, 6878, Tocris Bioscience

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