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Submit ReviewBMS 470539 dihydrochloride
说明： Potent, selective MC1 receptor agonist
化学名： 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for BMS 470539 dihydrochloride
BMS 470539 dihydrochloride is a potent, selective melanocortin MC1 receptor agonist (IC50 = 120 nM). Exhibits anti-inflammatory properties following ischemia-reperfusion in the vasculature. Inhibits leukocyte trafficking.
技术数据 for BMS 470539 dihydrochloride
| 分子量 | 632.62 |
| 公式 | C32H41N5O4.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2341796-82-3 |
| PubChem ID | 60210130 |
| InChI Key | DUAOBJHRUKFKIH-YDVFRNEYSA-N |
| Smiles | O=C(N2CCC(C(CCC)=O)(C4=CC=CC=C4)CC2)[C@H](NC([C@@H](N)CC3=CN=CN3C)=O)CC1=CC=C(OC)C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BMS 470539 dihydrochloride
参考文献 for BMS 470539 dihydrochloride
参考文献是支持产品生物活性的出版物。
Herpin et al (2003) Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J.Med.Chem. 46 1123 PMID: 12646021
Leoni et al (2010) The melanocortin MC1 receptor agonist BMS-470539 inhibits leukocyte trafficking in the inflamed vasculature. Br.J.Pharmacol. 160 171 PMID: 20331604
Kang (2006) A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice. J.Leukoc.Biol. 80 897 PMID: 16888084
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关键词: BMS 470539 dihydrochloride, BMS 470539 dihydrochloride supplier, BMS470539, melanocortin, agonist, MC1, agonists, anti-inflammatory, 457893-92-4, Melanocortin, Receptors, 4053, Tocris Bioscience
1 篇 BMS 470539 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BMS 470539 dihydrochloride 的部分引用包括：
Jain et al (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab 315 E357 PMID: 29812984
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