BMS 599626 dihydrochloride

Name: BMS 599626 dihydrochloride
Brand: Tocris Bioscience
SKU: 5022

Cat. No. 5022 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5022 has been discontinued.

View all EGFR products.

说明： Potent, selective EGFR and ErbB2 inhibitor

化学名： (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamate dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for BMS 599626 dihydrochloride

BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC₅₀ values are 22 nM and 32 nM respectively). Also inhibits HER4 (IC₅₀ = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. Antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Orally bioavailable.

技术数据 for BMS 599626 dihydrochloride

分子量	603.48
公式	C₂₇H₂₇FN₈O₃.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1781932-33-9
PubChem ID	90488998
InChI Key	SKHKFWSXLCGMNF-IKXQUJFKSA-N
Smiles	FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C)C(NC(OC[C@@H]6COCCN6)=O)=C5)=C3)=CC=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BMS 599626 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BMS 599626 dihydrochloride

参考文献是支持产品生物活性的出版物。

Wong et al (2006) Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin.Cancer Res. 12 6186 PMID: 17062696

Gavai et al (2009) Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficaciou J.Med.Chem. 52 6527 PMID: 19821562

按标靶查看相关产品

按产品操作查看相关产品

查看全部 EGFR Inhibitors

关键词: BMS 599626 dihydrochloride, BMS 599626 dihydrochloride supplier, BMS599626, potent, selective, HER1, HER2, EGFR, erbB-2, erbB2, tyrosine, kinase, inhibitors, inhibits, kinases, receptors, growth, factor, Neu, antitumor, antitumour, antiproliferative, 5022, Tocris Bioscience

篇 BMS 599626 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 BMS 599626 dihydrochloride 的引用文献。