BMS 605541

Name: BMS 605541
Brand: Tocris Bioscience
SKU: 6069

Cat. No. 6069 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6069 has been discontinued.

View all VEGFR products.

说明： Potent VEGFR-2 inhibitor

化学名： N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for BMS 605541

BMS 605541 is a potent ATP-competitive VEGFR-2 inhibitor (IC₅₀ = 23 nM). Shows >10-fold selectivity for VEGFR-2 over VEGFR-1. Displays antitumor properties in human lung and colon tumor xenograft models. Orally bioavailable in rodents.

技术数据 for BMS 605541

分子量	401.43
公式	C₁₉H₁₇F₂N₅O_S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	639858-32-5
PubChem ID	11632737
InChI Key	CUPLTRAPYIXFAX-UHFFFAOYSA-N
Smiles	FC1=C(NCC2=CN=C(NC3=NC=CC=C3)S2)C=C(C(NC4CC4)=O)C(F)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BMS 605541

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BMS 605541

参考文献是支持产品生物活性的出版物。

Borzilleri et al (2006) Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J.Med.Chem 49 3766 PMID: 16789733

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关键词: BMS 605541, BMS 605541 supplier, BMS605541, VEFGR-2, inhibitors, inhibits, antitumor, VEGFR, 6069, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for BMS 605541

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.