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Submit ReviewBMS 688521
说明： Potent inhibitor of the LFA-1/ICAM interaction
化学名： 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for BMS 688521
BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively). Inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model.
化合物库 for BMS 688521
BMS 688521 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BMS 688521
| 分子量 | 536.37 |
| 公式 | C26H19Cl2N5O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 893397-44-9 |
| PubChem ID | 11699447 |
| InChI Key | LILGMDXLRPEBNH-HFZDXXHNSA-N |
| Smiles | CN1C(=O)N(C(=O)[C@]11CN(C[C@H]1C1=CC=C(C=C1)C#N)C1=NC=C(C=C1)C(O)=O)C1=CC(Cl)=CC(Cl)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BMS 688521
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 53.64 | 100 |
制备储备液 for BMS 688521
以下数据基于产品分子量 536.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.86 mL | 9.32 mL | 18.64 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.73 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.86 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
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产品说明书 for BMS 688521
参考文献 for BMS 688521
参考文献是支持产品生物活性的出版物。
Watterson et al (2010) Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4] J.Med.Chem. 53 3814 PMID: 20405922
If you know of a relevant reference for BMS 688521, please let us know.
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关键词: BMS 688521, BMS 688521 supplier, BMS688521, LFA-1, antagonists, blocker, interaction, inhibitors, inhibits, ICAM1, lymphocyte, function, associated, antigen, intracellular, adhesion, molecule, potent, Integrins, Cell, Adhesion, Molecules, 4970, Tocris Bioscience
1 篇 BMS 688521 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BMS 688521 的部分引用包括：
Jing et al (2019) CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells. Cell Rep 28 2892-2904.e7 PMID: 31509750
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