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Submit ReviewBMS 795311
说明： Potent cholesteryl ester transfer protein (CETP) inhibitor
化学名： N-[(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide
纯度： ≥98% (HPLC)
生物活性 for BMS 795311
BMS 795311 is a potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable.
技术数据 for BMS 795311
| 分子量 | 671.52 |
| 公式 | C33H23F10NO3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 939390-99-5 |
| PubChem ID | 23582473 |
| InChI Key | UBJMOTPQBCKENW-WJOKGBTCSA-N |
| Smiles | FC1=CC(OC(F)(F)C(F)F)=CC([C@@](NC(C2=CC=C(F)C(C(F)(F)F)=C2)=O)(CC3=CC=CC=C3)C4=CC=C(F)C(OC5CC5)=C4)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BMS 795311
参考文献 for BMS 795311
参考文献是支持产品生物活性的出版物。
Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID: 26524347
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关键词: BMS 795311, BMS 795311 supplier, BMS795311, cholesteryl, ester, transfer, protein, CETP, potent, inhibitors, inhibits, orally, bioavailable, high, density, lipoprotein, cholesterol, HDL-C, Other, Transferases, Lipid, Metabolism, 5762, Tocris Bioscience
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