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BMS 986094

Cat. No. 6974 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6974 has been discontinued.

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说明： Inhibitor of HCV RNA-dependent RNA polymerase (RdRP; NS5b); potent hepatitis C virus (HCV) replication inhibitor
别名： INX 08189
化学名： Neopentyl [[[(2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl]methoxy](naphthalen-1-yloxy)phosphoryl]-L-alaninate
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for BMS 986094

BMS 986094 is a potent hepatitis C virus (HCV) replication inhibitor (EC50 = 35 nM). Is rapidly metabolized in primary human hepatocytes to 2'-C-methyl guanosine triphosphate, an inhibitor of HCV RNA-dependent RNA polymerase NS5b. Displays 10-fold reduction in potency in S282T mutant-expressing versus wild-type replicons. Exhibits synergy with Ribavirin (Cat. No. 4501). Orally bioavailable.

技术数据 for BMS 986094

分子量 658.65
公式 C30H39N6O9P
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1234490-83-5
PubChem ID 46700744
InChI Key YFXGICNMLCGLHJ-RSKRLRQZSA-N
Smiles COC1=C2N=CN([C@@H]3O[C@H](CO[P](=O)(N[C@@H](C)C(=O)OCC(C)(C)C)OC4=CC=CC5=C4C=CC=C5)[C@@H](O)[C@@]3(C)O)C2=NC(N)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for BMS 986094

参考文献是支持产品生物活性的出版物。

Vernachio et al (2011) INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties. Antimicrob.Agents Chemother. 55 1843 PMID: 21357300

McGuigan et al (2010) Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus. Bioorg.Med.Chem.Lett. 20 4850 PMID: 20637609

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关键词: BMS 986094, BMS 986094 supplier, BMS986094, HCV, RNA, polymerase, NS5b, inhibitors, inhibits, hepatitis, C, virus, potent, prodrug, replication, orally, bioavailable, INX, 08189, Polymerase, Hepatitis, Viruses, 6974, Tocris Bioscience

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