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Submit ReviewBMY 45778
说明： Non-prostanoid prostacyclin IP receptor partial agonist
化学名： [3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid
纯度： ≥99% (HPLC)
生物活性 for BMY 45778
BMY 45778 is a non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC50 = 27-35 nM).
许可信息
Sold with the permission of Bristol-Myers Squibb Company
技术数据 for BMY 45778
| 分子量 | 438.44 |
| 公式 | C26H18N2O5 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 152575-66-1 |
| PubChem ID | 127861 |
| InChI Key | DSRSEEYZGWTODH-UHFFFAOYSA-N |
| Smiles | OC(=O)COC1=CC(=CC=C1)C1=C(N=CO1)C1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BMY 45778
参考文献 for BMY 45778
参考文献是支持产品生物活性的出版物。
Meanwell et al (1993) Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid. 36 3884 PMID: 7504734
Rudd et al (2000) Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon. Br.J.Pharmacol. 129 782 PMID: 10683203
Seiler et al (1997) [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and ilo. binding. Prostaglandins 53 21 PMID: 9068064
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关键词: BMY 45778, BMY 45778 supplier, Non-prostanoid, prostacyclin, IP1, receptor, partial, agonist, Receptors, Prostanoid, PGI, prostaglandins, prostacyclins, eicosanoids, BMY45778, 1442, Tocris Bioscience
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