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Submit ReviewBoc-MLF
说明： FPR1 antagonist
纯度： ≥95% (HPLC)
生物活性 for Boc-MLF
Boc-MLF is an antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.
技术数据 for Boc-MLF
| 分子量 | 509.66 |
| 公式 | C25H39N3O6S |
| 序列 | Boc-MLF |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 67247-12-5 |
| PubChem ID | 14655143 |
| InChI Key | GYBXWOPENJVQKE-UFYCRDLUSA-N |
| Smiles | O=C([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CCSC)=O)CC(C)C)N[C@H]([C@@](O)=O)CC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Boc-MLF
| 溶解性 | Soluble to 2 mg/ml in DMSO |
产品说明书 for Boc-MLF
参考文献 for Boc-MLF
参考文献是支持产品生物活性的出版物。
Boxio et al (2005) The immunostimulatory peptide WKYMVm-NH2 activates bone marrow mouse neutrophils via multiple signal transduction pathways. Scand.J.Immunol. 62 140 PMID: 16101820
Stenfeldt et al (2007) Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 30 224 PMID: 17687636
Karlsson et al (2005) Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol. 78 762
If you know of a relevant reference for Boc-MLF, please let us know.
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关键词: Boc-MLF, Boc-MLF supplier, formyl, peptide, receptor, 1, fMLF, FPR1, antagonists, Formyl, Peptide, Receptors, 3730, Tocris Bioscience
2 篇 Boc-MLF 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Boc-MLF 的部分引用包括：
Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199
Sedlmayer et al (2018) Designer cells programming quorum-sensing interference with microbes. Nat Commun 9 1822 PMID: 29739943
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