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说明： Antiangiogenic; inhibits threonyl-tRNA synthetase
化学名： (1R,2R)-2-[(2S,4E,6Z,8R,9S,11R,13S,15S,16S)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Borrelidin
Borrelidin is an antibiotic and antiangiogenic. Selectively inhibits threonyl-tRNA synthetase (ThrRS). Exhibits antiangiogenic activity in a mouse model of tumor angiogenesis. Induces apoptosis in capillary tube-forming endothelial cells; disrupts capillary tubes and inhibits their formation (IC50 = 0.8 nM in rat aorta). Induces the unfolded protein response (UPR) and apoptosis in oral cancer cells.
技术数据 for Borrelidin
| 分子量 | 489.64 |
| 公式 | C28H43NO6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 7184-60-3 |
| PubChem ID | 5357974 |
| InChI Key | OJCKRNPLOZHAOU-SLNPHPKOSA-N |
| Smiles | O[C@@H](C1)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@@H](O)\C(C#N)=C/C=C/C[C@]([C@]2([H])CCC[C@H]2C(O)=O)([H])OC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Borrelidin
参考文献 for Borrelidin
参考文献是支持产品生物活性的出版物。
Wakabayashi et al (1997) Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J.Antibiot.(Tokyo). 50 671 PMID: 9315080
Kawamura et al (2003) Anti-angiogenesis effect of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. J.Antibiot.(Tokyo). 56 709 PMID: 14563161
Woolard et al (2011) Borrelidin modulates the alterntive splicing of VEGF in favour of anti-antiogenic isoforms. Chem.Sci. 273 PMID: 22822423
Sidhu et al (2015) Borrelidin induces the unfolded protein response in oral cancer cells and Chop-dependent apoptosis. ACS Med.Chem.Lett. 6 1122 PMID: 26617965
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关键词: Borrelidin, Borrelidin supplier, antibacterials, antibiotics, threonyl-tRNA, synthetase, ThrRS, antiangiogenics, capillary, capillaries, formation, inhibitors, inhibits, Other, Synthases/Synthetases, Antiangiogenics, Antibiotics, 4706, Tocris Bioscience
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