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Bosentan

Cat. No. 6232 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity dual ETA and ETB receptor antagonist;orally bioavailable
别名： Ro 47-0203
化学名： 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bosentan

Bosentan is a high affinity dual ETA and ETB receptor antagonist (Ki values are 4.7 and 95 nM for ETA and ETB, respectively). Inhibits ET-1 induced contraction of isolated rat aorta and sarafotoxin S6C-induced contraction of rat trachea in vitro. Orally bioavailable.

化合物库 for Bosentan

Bosentan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Bosentan

分子量 551.61
公式 C27H29N5O6S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 147536-97-8
PubChem ID 104865
InChI Key GJPICJJJRGTNOD-UHFFFAOYSA-N
Smiles COC1=C(C=CC=C1)OC2=C(N=C(C3=NC=CC=N3)N=C2NS(=O)(C4=CC=C(C(C)(C)C)C=C4)=O)OCCO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bosentan

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 55.16 100
ethanol 27.58 50

制备储备液 for Bosentan

以下数据基于产品分子量 551.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.06 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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参考文献 for Bosentan

参考文献是支持产品生物活性的出版物。

Clozel et al (1994) Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J.Pharmacol.Exp.Ther. 270 228 PMID: 8035319

Gardiner et al (1994) Effects of bos. (Ro 47-0203), an ETA-, ETB-receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats. Br.J.Pharmacol. 112 823 PMID: 7921608

If you know of a relevant reference for Bosentan, please let us know.

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关键词: Bosentan, Bosentan supplier, High, affinity, endothelin, antagonists, antagonism, ETA, ETB, orally, bioavailable, Ro470203, Ro, 47-0203, Non-selective, Endothelin, 6232, Tocris Bioscience

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