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说明： Non-competitive GC inhibitor. Also AC inhibitor
化学名： 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
纯度： ≥99% (HPLC)
生物活性 for BPIPP
Non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.
技术数据 for BPIPP
| 分子量 | 450.28 |
| 公式 | C22H16BrN3O3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 325746-94-9 |
| PubChem ID | 4410990 |
| InChI Key | QSZKQDDYOLAPII-UHFFFAOYSA-N |
| Smiles | O=C(C5=C4C=CC=C5)C2=C4NC(N1C)=C(C2C3=CC(Br)=CC=C3)C(N(C)C1=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BPIPP
参考文献 for BPIPP
参考文献是支持产品生物活性的出版物。
Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440
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关键词: BPIPP, BPIPP supplier, Non-competitive, GC, inhibitors, inhibits, Guanylyl, Cyclases, Cyclase, Adenylyl, 3635, Tocris Bioscience
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