BPTU

Cat. No. 6078 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： P2Y₁ allosteric antagonist

化学名： N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BPTU

BPTU is an allosteric antagonist of P2Y₁ (EC₅₀ = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced by electrical field stimulation, nicotine and P2Y agonists. Antithrombotic; reduces platelet aggregation.

技术数据 for BPTU

分子量	445.43
公式	C₂₃H₂₂F₃N₃O₃
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	870544-59-5
PubChem ID	11510579
InChI Key	AHFLGPTXSIRAQK-UHFFFAOYSA-N
Smiles	CC(C)(C1=C(C=CC=C1)OC2=C(C=CC=N2)NC(NC3=CC=C(C=C3)OC(F)(F)F)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BPTU

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	44.54	100
	ethanol	44.54	100

制备储备液 for BPTU

以下数据基于产品分子量 445.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.23 mL	22.45 mL
5 mM	0.45 mL	2.25 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.25 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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产品说明书 for BPTU

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BPTU

参考文献是支持产品生物活性的出版物。

Chao et al (2013) Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. J.Med.Chem. 2013 1704 PMID: 23368907

Zhang et al (2015) Two disparate ligand-binding sites in the human P2Y1 receptor. Nature. 2015 317 PMID: 25822790

Mañé et al (2016) BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. Neuropharmacology. 2016 376 PMID: 27496690

If you know of a relevant reference for BPTU, please let us know.

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Purinergic (P2Y) Receptors

关键词: BPTU, BPTU supplier, P2Y1, antagonists, antagonism, antithrombotic, non-nucleotide, ligand, spontaneous, contraction, allosteric, NAM, Purinergic, P2Y, Receptors, 6078, Tocris Bioscience

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P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.