BRACO 19 trihydrochloride

Cat. No. 5312 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Telomerase inhibitor

化学名： N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride

纯度： ≥94% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BRACO 19 trihydrochloride

BRACO 19 trihydrochloride is a telomerase inhibitor (IC₅₀ = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.

技术数据 for BRACO 19 trihydrochloride

分子量	703.14
公式	C₃₅H₄₃N₇O₂.3HCl
储存	Store at -20°C
纯度	≥94% (HPLC)
CAS Number	1177798-88-7
PubChem ID	10349800
InChI Key	MJAPNWJRLLDPAB-UHFFFAOYSA-N
Smiles	O=C(CCN5CCCC5)NC3=CC2=NC1=CC(NC(CCN6CCCC6)=O)=CC=C1C(NC4=CC=C(N(C)C)C=C4)=C2C=C3.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BRACO 19 trihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	35.16	50
	DMSO	35.16	50

制备储备液 for BRACO 19 trihydrochloride

以下数据基于产品分子量 703.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	2.84 mL	14.22 mL	28.44 mL
2.5 mM	0.57 mL	2.84 mL	5.69 mL
5 mM	0.28 mL	1.42 mL	2.84 mL
25 mM	0.06 mL	0.28 mL	0.57 mL

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产品说明书 for BRACO 19 trihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BRACO 19 trihydrochloride

参考文献是支持产品生物活性的出版物。

Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID: 11961134

Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID: 15735037

If you know of a relevant reference for BRACO 19 trihydrochloride, please let us know.

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