Brain natriuretic peptide (1-32) (human)

Name: Brain natriuretic peptide (1-32) (human)
Brand: Tocris Bioscience
SKU: 3522
Rating: 5 (1 reviews)

Cat. No. 3522 1 次引用 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Endogenous peptide agonist at ANP receptor A (NPR1)

纯度： ≥95% (HPLC)

说明书

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性

Brain natriuretic peptide (1-32) (human) is an endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de novo collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vivo.

技术数据

分子量	3464.05
公式	C₁₄₃H₂₄₄N₅₀O₄₂S₄
序列	SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (Modification: Disulfide bridge: 10-26)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	124584-08-3
PubChem ID	53325981
InChI Key	HPNRHPKXQZSDFX-OAQDCNSJSA-N
Smiles	[H]N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

溶解性	Soluble to 0.10 mg/ml in water

产品说明书

分析证书/产品说明书

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参考文献

参考文献是支持产品生物活性的出版物。

Tsuruda et al (2002) Brain natriuretic peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Circ.Res. 91 1127 PMID: 12480813

Wellard et al (2006) Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo. Neurosci.Lett. 392 187 PMID: 16278044

Heublein et al (2007) Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various forms of human B-type natriuretic peptide. Hypertension 49 1114 PMID: 17372040

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关键词: Brain natriuretic peptide (1-32) (human), Brain natriuretic peptide (1-32) (human) supplier, Endogenous, peptide, agonists, ANP, receptor, A, NRP1, Receptors, Atrial, Natriuretic, Peptide, Receptor, 3522, Tocris Bioscience

1 篇 Brain natriuretic peptide (1-32) (human) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Brain natriuretic peptide (1-32) (human) 的部分引用包括：

Wang et al (2017) GDF15 is a heart-derived hormone that regulates body growth. EMBO Mol Med 9 1150 PMID: 28572090

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