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Submit ReviewBRD 6989
说明： Cdk8 inhibitor; enhances IL-10 production
化学名： 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
纯度： ≥97% (HPLC)
生物活性 for BRD 6989
Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.
化合物库 for BRD 6989
BRD 6989 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BRD 6989
| 分子量 | 264.33 |
| 公式 | C16H16N4 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 642008-81-9 |
| PubChem ID | 3835861 |
| InChI Key | QSYBDNXNOJIKML-UHFFFAOYSA-N |
| Smiles | CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BRD 6989
参考文献 for BRD 6989
参考文献是支持产品生物活性的出版物。
Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID: 28805801
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关键词: BRD 6989, BRD 6989 supplier, BRD6989, IL-10, production, enhancers, CDK8, inhibitors, enhances, inhibits, Cytokines, Transcriptional, CDKs, 6438, Tocris Bioscience
1 篇 BRD 6989 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BRD 6989 的部分引用包括：
Stephen P et al (2021) Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress. Nucleic Acids Res PMID: 34329458
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