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BRD 6989

Cat. No. 6438 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cdk8 inhibitor; enhances IL-10 production
化学名： 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BRD 6989

Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.

化合物库 for BRD 6989

BRD 6989 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BRD 6989

分子量 264.33
公式 C16H16N4
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 642008-81-9
PubChem ID 3835861
InChI Key QSYBDNXNOJIKML-UHFFFAOYSA-N
Smiles CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BRD 6989

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.29 20

制备储备液 for BRD 6989

以下数据基于产品分子量 264.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 18.92 mL 94.58 mL 189.16 mL
1 mM 3.78 mL 18.92 mL 37.83 mL
2 mM 1.89 mL 9.46 mL 18.92 mL
10 mM 0.38 mL 1.89 mL 3.78 mL

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参考文献 for BRD 6989

参考文献是支持产品生物活性的出版物。

Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID: 28805801

If you know of a relevant reference for BRD 6989, please let us know.

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关键词: BRD 6989, BRD 6989 supplier, BRD6989, IL-10, production, enhancers, CDK8, inhibitors, enhances, inhibits, Cytokines, Transcriptional, CDKs, 6438, Tocris Bioscience

1 篇 BRD 6989 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BRD 6989 的部分引用包括：

Stephen P et al (2021) Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress. Nucleic Acids Res PMID: 34329458

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