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Submit ReviewBRD 73954
说明： Dual histone deacetylase (HDAC) 6/8 inhibitor
化学名： N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
纯度： ≥98% (HPLC)
生物活性 for BRD 73954
BRD 73954 is a dual histone deacetylase (HDAC) 6/8 inhibitor. IC50 values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively.
化合物库 for BRD 73954
BRD 73954 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BRD 73954
| 分子量 | 284.31 |
| 公式 | C16H16N2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1440209-96-0 |
| PubChem ID | 71680913 |
| InChI Key | FIHKWEQJEDRIFS-UHFFFAOYSA-N |
| Smiles | ONC(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BRD 73954
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.43 | 100 | |
| ethanol | 5.69 | 20 温和加热 |
制备储备液 for BRD 73954
以下数据基于产品分子量 284.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 5 mM | 0.7 mL | 3.52 mL | 7.03 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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产品说明书 for BRD 73954
参考文献 for BRD 73954
参考文献是支持产品生物活性的出版物。
Olson et al (2013) Discovery of the first histone deacetylase 6/8 dual inhibitors. J.Med.Chem. 56 4816 PMID: 23672185
If you know of a relevant reference for BRD 73954, please let us know.
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关键词: BRD 73954, BRD 73954 supplier, BRD73954, Histone, deacetylase, inhibitors, inhibits, HDAC6, HDAC8, HDAC, Class, I, HDACs, II, 6284, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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