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BSJ-Bump

Cat. No. 6922 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6922 has been discontinued.

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说明： Negative control for BSJ-03-123 (Cat. No. 6921)
化学名： N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for BSJ-Bump

BSJ-Bump is a negative control for BSJ-03-123 (Cat. No. 6921). Displays binding and no degradation of Cdk6 in vitro.

许可信息

Sold under license from Dana-Farber Cancer Institute

技术数据 for BSJ-Bump

分子量 951.05
公式 C48H58N10O11
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2409918-48-3
Smiles O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N5CCN(CC5)CCOCCOCCOCCNC(COC6=C(C7=CC=C6)C(N(C7=O)C8C(N(C)C(CC8)=O)=O)=O)=O)C=N4)=NC=C3C(C)=C1C(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for BSJ-Bump

参考文献是支持产品生物活性的出版物。

Brand et al (2019) Homolog-selective degradation as a strategy to probe the function of CDK6 in AML. Cell Chem.Biol. 26 300 PMID: 30595531

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关键词: BSJ-Bump, BSJ-Bump supplier, protac, negative, control, proteolysis, targeting, chimera, cdk6, cyclin, dependent, kinase, 6, degraders, protacs, Negative, Controls, 6922, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia