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BSJ-03-123

Cat. No. 6921 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective Cdk6 Degrader (PROTAC®)
Chemical Name: N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BSJ-03-123

BSJ-03-123 is a selective Cdk6 Degrader (PROTAC®) (DC50 in sub 10 μM range). Displays no degradation of closely related Cdk4.

Negative control BSJ-Bump (Cat. No. 6922) and Cdk6 antibody validated for Western Blot also available: Catalog # NBP1-87262.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for BSJ-03-123

M. Wt 937.02
Formula C47H56N10O11
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2361493-16-3
PubChem ID 137628658
InChI Key LUHCYAOYQIFNRN-UHFFFAOYSA-N
Smiles O=C1N(C2=NC(NC3=CC=C(C=N3)N4CCN(CCOCCOCCOCCNC(COC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)CC4)=NC=C2C(C)=C1C(C)=O)C8CCCC8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BSJ-03-123

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 93.7 100

Preparing Stock Solutions for BSJ-03-123

The following data is based on the product molecular weight 937.02. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.07 mL 5.34 mL 10.67 mL
5 mM 0.21 mL 1.07 mL 2.13 mL
10 mM 0.11 mL 0.53 mL 1.07 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

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References for BSJ-03-123

References are publications that support the biological activity of the product.

Brand et al (2019) Homolog-selective degradation as a strategy to probe the function of CDK6 in AML. Cell Chem.Biol. 26 300 PMID: 30595531

If you know of a relevant reference for BSJ-03-123, please let us know.

View Related Products by Target

Keywords: BSJ-03-123, BSJ-03-123 supplier, cyclin, dependent, kinase, cdk6, active, degraders, degrades, selective, protac, proteolysis, targeting, chimera, PROTACs, CDK4, Subfamily, Cyclin, Dependent, Kinase, (CDK), Degraders, 6921, Tocris Bioscience

Citations for BSJ-03-123

Citations are publications that use Tocris products.

Currently there are no citations for BSJ-03-123. Do you know of a great paper that uses BSJ-03-123 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia