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Submit ReviewBVD 10
说明： Highly selective NPY Y1 receptor antagonist; devoid of Y4 agonist activity
生物活性 for BVD 10
Highly selective NPY Y1 receptor antagonist. Ki values are 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors respectively. Devoid of agonist activity at Y4 receptors.
许可信息
Sold under license
技术数据 for BVD 10
| 分子量 | 1221.46 |
| 公式 | C58H92N16O13 |
| 序列 |
INPIYRLRY (Modifications: Tyr-9 = Tyr-OMe) |
| 储存 | Store at -20°C |
| CAS Number | 262418-00-8 |
| PubChem ID | 10820196 |
| InChI Key | JLQHEFJKMUJISI-QUCBMPEKSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BVD 10
参考文献 for BVD 10
参考文献是支持产品生物活性的出版物。
Balasubramaniam et al (2001) Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90). J.Med.Chem. 44 1479 PMID: 11334558
Jois and Balasubramaniam (2003) Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides 24 1035 PMID: 14499282
Jois et al (2006) Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist. J.Biomol.Struct.Dyn. 23 497 PMID: 16494499
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关键词: BVD 10, BVD 10 supplier, selective, Y1, antagonists, devoid, Y4, agonists, activity, Neuropeptide, Y, Receptors, NPY, BVD10, neuropeptides, 2177, Tocris Bioscience
1 篇 BVD 10 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BVD 10 的部分引用包括：
Demorrow et al (2011) Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion. Physiol Rep 300 C1078 PMID: 21270292
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.