NPY Receptors
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake and modulation of circadian rhythm.
NPY Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1153 | Neuropeptide Y (human, rat) |
| Influences feeding and sexual behavior | |
| 1176 | [Leu31,Pro34]-Neuropeptide Y (human, rat) |
| NPY Y1 receptor agonist | |
| 1154 | Pancreatic Polypeptide (human) |
| NPY Y4 agonist; involved in gastrointestinal tract function | |
| 1618 | Peptide YY (3-36) |
| Selective NPY Y2 receptor agonist | |
NPY Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2412 | BIBO 3304 trifluoroacetate |
| Highly selective NPY Y1 receptor antagonist | |
| 2707 | BIBP 3226 trifluoroacetate |
| Mixed NPY Y1 and NPFF receptor antagonist | |
| 7377 | BIIE 0246 hydrochloride |
| Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo | |
| 3242 | BMS 193885 |
| Potent, competitive NPY Y1 receptor antagonist | |
| 2199 | CGP 71683 hydrochloride |
| Highly selective and potent non-peptide NPY Y5 receptor antagonist | |
| 4606 | CYM 9484 |
| Potent NPY Y2 receptor antagonist | |
| 1382 | L-152,804 |
| Potent, selective non-peptide NPY Y5 receptor antagonist | |
| 3562 | LU AA33810 |
| Potent NPY Y5 receptor antagonist | |
| 3898 | SF 11 |
| NPY Y2 receptor antagonist | |
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release.
All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.
External sources of pharmacological information for NPY Receptors :
Literature for NPY Receptors
Tocris offers the following scientific literature for NPY Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Neuropeptide Y (NPY) Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| Y1 | Human | NPY1R | NM_000909 | P25929 |
| Mouse | Npyr1 | NM_010934 | Q04573 | |
| Rat | Npy1r | NM_001013032 | P21555 | |
| Y2 | Human | NPY2R | NM_000910 | P49146 |
| Mouse | Npy2r | NM_008731 | P97295 | |
| Rat | Npy2r | NM_023968 | O70424 | |
| Y4 | Human | PPYR1 | NM_005972 | P50391 |
| Mouse | Ppyr1 | NM_008919 | Q61041 | |
| Rat | Ppyr1 | NM_031581 | Q63447 | |
| Y5 | Human | NPY5R | NM_006174 | Q15761 |
| Mouse | Npy5r | NM_016708 | O70342 | |
| Rat | Npy5r | NM_012869 | Q63634 |
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
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