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Submit ReviewBW 723C86 hydrochloride
说明： 5-HT2B agonist
化学名： α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for BW 723C86 hydrochloride
BW 723C86 hydrochloride is a selective 5-HT2B receptor agonist.
技术数据 for BW 723C86 hydrochloride
| 分子量 | 322.85 |
| 公式 | C16H18N2OS.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 160521-72-2 |
| PubChem ID | 5311036 |
| InChI Key | PYJBJMIBANAOFJ-UHFFFAOYSA-N |
| Smiles | Cl.CC(N)CC1=CNC2=CC=C(OCC3=CC=CS3)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BW 723C86 hydrochloride
参考文献 for BW 723C86 hydrochloride
参考文献是支持产品生物活性的出版物。
Kennett et al (1997) BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology 36 233 PMID: 9144661
Kennett et al (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37 1603 PMID: 9886683
Duxon et al (1997) Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat. Neuropharmacology 36 601 PMID: 9225285
Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395 PMID: 21789169
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关键词: BW 723C86 hydrochloride, BW 723C86 hydrochloride supplier, 5-HT2B, agonist, Serotonin, Receptors, BW723C86, hydrochloride, 1059, Tocris Bioscience
11 篇 BW 723C86 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BW 723C86 hydrochloride 的部分引用包括：
Szabo (2018) Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Sci Rep 8 1765 PMID: 29379077
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One 3 e00103 PMID: 25692021
Tharayil et al (2010) Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. Neurogastroenterol Motil 22 462 PMID: 19941613
Hernandez et al (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Pharmacol Res Perspect 302 E1009 PMID: 22318950
Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. J Pharmacol Exp Ther 6 e21395 PMID: 21789169
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Mbaki (2008) Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol 155 343 PMID: 18604238
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728
Wouters et al (2009) Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem 284 21177 PMID: 19531484
Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714
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5-HT has a potential for relaxant.
By
Anonymous on 02/18/2020
分析类型： In Vivo
种属： Rat
We used 10nM (5-HT2B partial agonist) BW723C86
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.