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C 101248

Cat. No. 8007 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective and potent inhibitor of both mouse and human THIK-1
化学名： 4-[1-(4-Pyridinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for C 101248

C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50 = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and Kv2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1β in isolated microglia.

技术数据 for C 101248

分子量 292.3
公式 C15H12N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 361368-24-3
PubChem ID 723233
InChI Key LXADAVBNVFYEBW-UHFFFAOYSA-N
Smiles NC1=NON=C1C2=NC3=CC=CC=C3N2CC4=CC=NC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for C 101248

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.23 100

制备储备液 for C 101248

以下数据基于产品分子量 292.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.11 mL 34.21 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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参考文献 for C 101248

参考文献是支持产品生物活性的出版物。

Ossola et al (2022) Characterisation of C101248: a novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome. Neuropharmacology 224 109330 PMID: 36375694

If you know of a relevant reference for C 101248, please let us know.

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关键词: C 101248, C 101248 supplier, C101248, tandem, pore, domain, halothane-inhibited, K+, channel, 1, inhibitor, inhibits, THIK-1, KCNK13, THIK1, potassium, potent, selective, NLRP3, IL1b, IL1beta, Two-P, Potassium, Channels, 8007, Tocris Bioscience

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