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C 176

Cat. No. 7040 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： mSTING antagonist
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for C 176

C 176 is a mSTING antagonist. Covalently binds Cys91 of mouse but not human STING. Blocks activation-induced palmitoylation of STING and formation of STING clusters. Reduces CMA (Cat. No. 6677) -induced increase in serum IFNs in vivo and suppresses systemic inflammation in a mouse inflammatory disease model.

技术数据 for C 176

分子量 358.09
公式 C11H7IN2O4
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 314054-00-7
PubChem ID 1103958
InChI Key JBIKQXOZLBLMKI-UHFFFAOYSA-N
Smiles IC1=CC=C(C=C1)NC(C2=CC=C([N+]([O-])=O)O2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for C 176

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.81 100

制备储备液 for C 176

以下数据基于产品分子量 358.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.96 mL 27.93 mL
5 mM 0.56 mL 2.79 mL 5.59 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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参考文献 for C 176

参考文献是支持产品生物活性的出版物。

Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723

If you know of a relevant reference for C 176, please let us know.

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关键词: C 176, C 176 supplier, C176, mSTING, murine, mouse, stimulator, of, interferon, genes, antagonists, antagonism, covalent, covalently, STING-Dependent, Signaling, 7040, Tocris Bioscience

1 篇 C 176 的引用文献

引用文献是使用了 Tocris 产品的出版物。 C 176 的部分引用包括：

Kevin C et al (2023) Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies. J Exp Med 220 PMID: 36534085

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