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Submit ReviewC-DIM 12
说明： Nurr1 activator; inhibits NF-κB-dependent gene expression
化学名： 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
纯度： ≥98% (HPLC)
生物活性 for C-DIM 12
C-DIM 12 is a nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.
技术数据 for C-DIM 12
| 分子量 | 356.85 |
| 公式 | C23H17ClN2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 178946-89-9 |
| PubChem ID | 5302583 |
| InChI Key | LTLRXTDMXOFBDW-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for C-DIM 12
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.69 | 100 | |
| ethanol | 35.69 | 100 |
制备储备液 for C-DIM 12
以下数据基于产品分子量 356.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 14.01 mL | 28.02 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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产品说明书 for C-DIM 12
参考文献 for C-DIM 12
参考文献是支持产品生物活性的出版物。
De Miranda et al (2013) Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. J.Pharmacol.Exp.Ther. 345 125 PMID: 23318470
De Miranda et al (2015) The Nurr1 activator 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor κB. Mol Pharmacol. 87 1021 PMID: 25858541
If you know of a relevant reference for C-DIM 12, please let us know.
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关键词: C-DIM 12, C-DIM 12 supplier, C-DIM12, Nurr1, activators, activates, NF-KB, NK-kappaB, NF-κB, signaling, signalling, orally, bioavailable, neuroprotective, neuroinflammation, NF-kB/IkB, Nerve, Growth, Factor, IB-like, Receptors, 5821, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for C-DIM 12
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.