C34

Cat. No. 5373 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： TLR4 inhibitor

别名： TLR4-IN-C34

化学名： 1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate

引用文献 (8)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for C34

C34 is a TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.

化合物库 for C34

C34 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for C34

分子量	389.4
公式	C₁₇H₂₇NO₉
储存	Store at -20°C
CAS Number	40592-88-9
PubChem ID	91691128
InChI Key	KMIQMFHPUJUDMC-HHARLNAUSA-N
Smiles	CC(OC[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](NC(C)=O)[C@@H](OC(C)C)O1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for C34

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	19.47	50
	DMSO	38.94	100

制备储备液 for C34

以下数据基于产品分子量 389.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for C34

分析证书/产品说明书

化学品安全技术说明书

参考文献 for C34

参考文献是支持产品生物活性的出版物。

Neal et al (2013) Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One 8 e65779 PMID: 23776545

If you know of a relevant reference for C34, please let us know.

按标靶查看相关产品

Toll-like Receptors

按产品操作查看相关产品

查看全部 Toll-like Receptor Inhibitors

关键词: C34, C34 supplier, TLR4, signaling, mediated, inflammatory, diseases, inhibitors, inhibits, endotoxemia, necrotizing, enterocolitis, NEC, TLR4-IN-C34, Toll-like, Receptors, 5373, Tocris Bioscience

8 篇 C34 的引用文献

引用文献是使用了 Tocris 产品的出版物。 C34 的部分引用包括：

Sun et al (2017) Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner. J Neuroinflammation 14 231 PMID: 29178911

Zhang et al (2019) CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol 20 7 PMID: 30674283

Zhou et al (2019) Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps. Oncol Lett 18 181 PMID: 31289487

Alessandro et al (2021) Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of Nucleophosmin in human cardiac mesenchymal progenitor cells. BMC Biol 19 124 PMID: 34134693

Maurizio C et al (2022) Extracellular Nucleophosmin Is Increased in Psoriasis and Correlates With the Determinants of Cardiovascular Diseases. Front Cardiovasc Med 9 867813 PMID: 35571214

Stephens et al (2019) Mesenteric Lymphatic Alterations Observed During DSS Induced Intestinal Inflammation Are Driven in a TLR4-PAMP/DAMP Discriminative Manner. Front Immunol 10 557 PMID: 30972059

Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752

Nara et al (2020) TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Sci Rep 10 17451 PMID: 33060735

您是否知道使用了 Tocris C34 的优秀论文？请告知我们.

C34 的评论

目前没有该产品的评论。 Be the first to review C34 and earn rewards!

Have you used C34?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for C34

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.

C34