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Discontinued Product
6549 has been discontinued.
View all Calcitonin and Related Receptors products.
说明： Amylin (AMY3) antagonist; brain penetrant
生物活性 for cAC 253
cAC 253 is an amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
许可信息
Sold under license from the University of Alberta, US patent 2,967,616, Canadian patent 15/705,789.
技术数据 for cAC 253
| 分子量 | 3009.36 |
| 公式 | C126H202N42O40S2 |
| 序列 |
CLGRLSQELHRLQTYPRTNTGSNTYC (Modifications: Cys-26 = C-terminal amide, Disulfide bridge between 1 - 26) |
| 储存 | Store at -20°C |
| PubChem ID | 134160250 |
| InChI Key | DFYJEZIYKFCAIZ-MNWLAJMMSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC1=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for cAC 253
参考文献 for cAC 253
参考文献是支持产品生物活性的出版物。
Soudy et al (2016) Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease. Alzheimers Dement. (N Y) 3 44 PMID: 29067318
Mietlicki-Baase (2018) Amylin in Alzheimer's disease: Pathological peptide or potential treatment? Neuropharmacology 136 287 PMID: 29233636
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关键词: cAC 253, cAC 253 supplier, cAC253, amylin, antagonists, antagonism, brain, penetrant, AMY3, amyloid, beta, β, Abeta, Calcitonin, and, Related, Receptors, Amyloid, Beta, Peptides, 6549, Tocris Bioscience
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