Calcitonin (human)

Pricing Availability   Qty
说明: Endogenous calcitonin agonist; inhibits bone resorption
纯度: ≥95% (HPLC)
说明书
引用文献
评论
文献 (1)

生物活性 for Calcitonin (human)

Calcitonin (human) is an endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.

技术数据 for Calcitonin (human)

分子量 3417.87
公式 C151H226N40O45S3
序列 CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP

(Modifications: Pro-32 = C-terminal amide, Disulfide bridge: 1-7)

储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 21215-62-3
PubChem ID 122705992
InChI Key LCQDOKHKNORMTQ-JKQNMTHDSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC1=O)[C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for Calcitonin (human)

溶解性 Soluble to 2 mg/ml in water

产品说明书 for Calcitonin (human)

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参考文献 for Calcitonin (human)

参考文献是支持产品生物活性的出版物。

Foster (1968) Calcitonin. A review of experimental and clinical investigations. Postgrad.Med.J. 44 411 PMID: 4871775

Bower and Hay (2016) Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development. Br.J.Pharmacol. 173 1883 PMID: 27061187

Lee et al (2016) Calcitonin and amylin receptor peptide interaction mechanisms. J.Biol.Chem. 291 16416 PMID: 27474777


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关键词: Calcitonin (human), Calcitonin (human) supplier, endogenous, calcitonin, receptors, agonists, agonism, inhibits, bone, resorption, Calcitonin, and, Related, Receptors, 6031, Tocris Bioscience

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