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Submit ReviewCalmidazolium chloride is a calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.
分子量 | 687.7 |
公式 | C31H23Cl7N2O |
储存 | Store at +4°C |
纯度 | ≥95% (HPLC) |
CAS Number | 57265-65-3 |
PubChem ID | 644274 |
InChI Key | YGEIMSMISRCBFF-UHFFFAOYSA-M |
Smiles | [Cl-].ClC1=CC=C(C=C1)C(N1C=C[N+](CC(OCC2=CC=C(Cl)C=C2Cl)C2=CC=C(Cl)C=C2Cl)=C1)C1=CC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 68.77 | 100 | |
ethanol | 68.77 | 100 |
以下数据基于产品分子量 687.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.45 mL | 7.27 mL | 14.54 mL |
5 mM | 0.29 mL | 1.45 mL | 2.91 mL |
10 mM | 0.15 mL | 0.73 mL | 1.45 mL |
50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
参考文献是支持产品生物活性的出版物。
Gietzen (1983) Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem.J. 216 611 PMID: 6141789
Harper and Daly (2000) Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochem.Pharmacol. 60 317 PMID: 10856426
Peppiatt et al (2004) Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem.J. 381 929 PMID: 15130089
If you know of a relevant reference for Calmidazolium chloride, please let us know.
关键词: Calmidazolium chloride, Calmidazolium chloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, R24571, R, 24571, 2561, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Calmidazolium chloride 的部分引用包括:
Hook et al (2014) Calmodulin enhances ribbon replenishment and shapes filtering of synaptic transmission by cone photoreceptors. J Gen Physiol 144 357 PMID: 25311636
Kim et al (2018) JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway. Sci Rep 8 6611 PMID: 29700375
Varadarajan et al (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8 e56603 PMID: 23457590
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