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SGC CAMKK2-1

Cat. No. 7877 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective CAMKK1/2 inhibitor
Chemical Name: 2-Cyclopentyl-4-[5-(3-methylphenyl)furo[2,3-b]pyridin-3-yl]benzoic acid
Purity: ≥95% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SGC CAMKK2-1

SGC CAMKK2-1 is a potent and selective Ca2+-calmodulin-dependent protein kinase kinase (CaMKK) inhibitor (CAMKK2 IC50 = 30 nM). Displays selectivity toward CAMKK1 and CAMKK2 over 404 kinases in a kinome wide screen (Discoverx). SGC CAMKK2-1 inhibits AMPK phosphorylation in C4-2 prostate cancer cells (IC50 = 1.6 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CAMKK2-1 probe summary on the SGC website.

Technical Data for SGC CAMKK2-1

M. Wt 397.47
Formula C26H23NO3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2561494-76-4
PubChem ID 154700451
InChI Key TXIYVFVMXNFNRX-UHFFFAOYSA-N
Smiles O=C(C1=C(C2CCCC2)C=C(C3=COC4=NC=C(C5=CC(C)=CC=C5)C=C43)C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SGC CAMKK2-1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.75 100

Preparing Stock Solutions for SGC CAMKK2-1

The following data is based on the product molecular weight 397.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for SGC CAMKK2-1

References are publications that support the biological activity of the product.

Wells et al (2023) SGC-CAMKK2-1: A chemical probe for CAMKK2. Cells 12 287 PMID: 36672221

If you know of a relevant reference for SGC CAMKK2-1, please let us know.

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Citations for SGC CAMKK2-1

Citations are publications that use Tocris products.

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