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Submit ReviewCALP1
说明： Cell-permeable calmodulin agonist
别名： Calcium-like peptide 1
生物活性 for CALP1
CALP1 is a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol (Cat.No. 1964) induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
技术数据 for CALP1
| 分子量 | 842.09 |
| 公式 | C40H75N9O10 |
| 序列 | VAITVLVK |
| 储存 | Desiccate at -20°C |
| CAS Number | 145224-99-3 |
| PubChem ID | 10440555 |
| InChI Key | HTOHLCKNMRKYLK-KVZSNLRASA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CALP1
参考文献 for CALP1
参考文献是支持产品生物活性的出版物。
Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297 PMID: 10877822
Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861 PMID: 11145661
Ten Broeke et al (2003) Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 476 151 PMID: 12969760
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652
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关键词: CALP1, CALP1 supplier, Cell-permeable, calmodulin, agonists, inhibitors, inhibits, Ca2+-sensitive, ion, channels, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calcium-like, peptide1, peptide, 1, Other, Channel, Modulators, 2090, Tocris Bioscience
2 篇 CALP1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CALP1 的部分引用包括：
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652
Tzeng et al (2012) The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res 96 533 PMID: 22886848
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