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说明： Cell-permeable calmodulin agonist
别名： Calcium-like peptide 3
生物活性 for CALP3
CALP3 is a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis (IC50 = 33 μM).
技术数据 for CALP3
| 分子量 | 881.08 |
| 公式 | C44H68N10O9 |
| 序列 | VKFGVGFK |
| 储存 | Desiccate at -20°C |
| CAS Number | 261969-05-5 |
| PubChem ID | 10033623 |
| InChI Key | OBMFGXCPBIYSPH-FFIZALLVSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CALP3
参考文献 for CALP3
参考文献是支持产品生物活性的出版物。
Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297 PMID: 10877822
Ten Broeke et al (2003) Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 476 151 PMID: 12969760
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676
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关键词: CALP3, CALP3 supplier, Cell-permeable, calmodulin, agonists, Ca2+, Binding, Protein, modulators, Calmodulin, Calcium, Signaling, Signalling, Calcium-like, peptide3, peptide, 3, 2321, Tocris Bioscience
1 篇 CALP3 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CALP3 的部分引用包括：
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 e2640 PMID: 28252652
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