cAMPS-Rp, triethylammonium salt

Name: cAMPS-Rp, triethylammonium salt
Brand: Tocris Bioscience
SKU: 1337
Rating: 5 (1 reviews)

Cat. No. 1337 13 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： cAMP antagonist

化学名： (R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium

纯度： ≥98% (HPLC)

说明书

引用文献 (13)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for cAMPS-Rp, triethylammonium salt

cAMPS-Rp, triethylammonium salt is a cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC₅₀ = 11 - 16 μM) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases.

技术数据 for cAMPS-Rp, triethylammonium salt

分子量	446.46
公式	C₁₀H₁₂N₅O₅PS.C₆H₁₅N
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	151837-09-1
PubChem ID	5311365
InChI Key	FKAWLXNLHHIHLA-YCBIHMBMSA-N
Smiles	[H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@@]1([S-])=O.CC[NH+](CC)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for cAMPS-Rp, triethylammonium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	44.65	100

制备储备液 for cAMPS-Rp, triethylammonium salt

以下数据基于产品分子量 446.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.2 mL	22.4 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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产品说明书 for cAMPS-Rp, triethylammonium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for cAMPS-Rp, triethylammonium salt

参考文献是支持产品生物活性的出版物。

Dostmann et al (1990) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 265 10484 PMID: 2162349

Fu et al (2008) PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol.Pain 4 26 PMID: 18631385

Kuriyama et al (1995) Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest.Ophthalmol.Vis.Sci. 36 730 PMID: 7890503

Rothermel and Botelho (1988) A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem.J. 251 757 PMID: 2843164

Van Haastert et al (1984) Competitive cAMP antagonists for cAMP-receptor proteins. J.Biol.Chem. 259 10020 PMID: 6088478

Duca et al (2015) MetF. activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat.Med. 21 506 PMID: 25849133

If you know of a relevant reference for cAMPS-Rp, triethylammonium salt, please let us know.

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关键词: cAMPS-Rp, triethylammonium salt, cAMPS-Rp, triethylammonium salt supplier, cAMP, analog, Cyclic, adenosines, Monophosphate, Rp-camps, Protein, Kinase, A, 1337, Tocris Bioscience

13 篇 cAMPS-Rp, triethylammonium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 cAMPS-Rp, triethylammonium salt 的部分引用包括：

Katrancha et al (2019) Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits. Cell Rep 26 2805 PMID: 30840899

Schwer et al (2013) Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death. PLoS One 8 e77258 PMID: 24167567

Tuesta (2017) GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci 20 708 PMID: 28368384

Inda et al (2017) cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells. Sci Rep 7 1944 PMID: 28512295

Inda et al (2016) Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol 214 181 PMID: 27402953

Cho et al (2012) Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci 32 14165 PMID: 23055486

Puerto et al (2012) Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation. J Cell Sci 125 176 PMID: 22250198

Silberman et al (2010) Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation. Neuropsychopharmacology 35 1886 PMID: 20410872

Crawford et al (2012) Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. Biochem Biophys Res Commun 32 13100 PMID: 22993427

Xu et al (2010) Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperDArgic mutant. Endocrinology 115 1643 PMID: 20969573

Xu et al (2018) Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β. EMBO Mol Med 10 PMID: 30093491

Tozzi et al (2015) Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system. Front Cell Neurosci 9 192 PMID: 26074768

Sutton et al (2005) Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. J Neurosci 146 3739 PMID: 15961554

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