Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCandesartan
说明： AT1 antagonist
别名： CV 11974
化学名： 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Candesartan
Candesartan is an angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).
化合物库 for Candesartan
Candesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Candesartan
| 分子量 | 440.45 |
| 公式 | C24H20N6O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 139481-59-7 |
| PubChem ID | 2541 |
| InChI Key | HTQMVQVXFRQIKW-UHFFFAOYSA-N |
| Smiles | CCOC1=NC(C=CC=C5C(O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Candesartan
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 4.45 | 100 | |
| ethanol | 0.44 | 10 温和加热 |
制备储备液 for Candesartan
以下数据基于产品分子量 440.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Candesartan
参考文献 for Candesartan
参考文献是支持产品生物活性的出版物。
Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552
If you know of a relevant reference for Candesartan, please let us know.
按产品操作查看相关产品
关键词: Candesartan, Candesartan supplier, Angiotensin, II, receptors, AT1, antagonists, CV11974, CV, 11974, Receptors, 4791, Tocris Bioscience
4 篇 Candesartan 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Candesartan 的部分引用包括：
Gemma et al (2021) Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clin Sci (Lond) 135 465-481 PMID: 33479758
Milan et al (2021) Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways. Front Neurosci 15 636259 PMID: 33828448
Ana et al (2022) Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the Substantia Nigra of Male Rodents and Primary Mesencephalic Cultures. Antioxidants (Basel) 11 PMID: 35204211
Rita et al (2022) Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease. NPJ Parkinsons Dis 8 76 PMID: 35701430
您是否知道使用了 Tocris Candesartan 的优秀论文？ 请告知我们.
Candesartan 的评论
目前没有该产品的评论。 Be the first to review Candesartan and earn rewards!
Have you used Candesartan?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image