Canertinib dihydrochloride

Cat. No. 5916 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent EGFR kinase inhibitor

别名： CI 1033,PD 183805

化学名： N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Canertinib dihydrochloride

Canertinib dihydrochloride is a potent EGFR kinase inhibitor (IC₅₀ = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for Canertinib dihydrochloride

分子量	558.86
公式	C₂₄H₂₅ClFN₅O_3.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	289499-45-2
PubChem ID	156413
InChI Key	JZZFDCXSFTVOJY-UHFFFAOYSA-N
Smiles	O=C(C=C)NC1=C(OCCCN4CCOCC4)C=C(N=CN=C2NC3=CC(Cl)=C(F)C=C3)C2=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Canertinib dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	11.18	20
	DMSO	55.89	100

制备储备液 for Canertinib dihydrochloride

以下数据基于产品分子量 558.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.79 mL	8.95 mL	17.89 mL
5 mM	0.36 mL	1.79 mL	3.58 mL
10 mM	0.18 mL	0.89 mL	1.79 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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产品说明书 for Canertinib dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Canertinib dihydrochloride

参考文献是支持产品生物活性的出版物。

Smaill et al (2000) Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J.Med.Chem. 43 1380 PMID: 10753475

If you know of a relevant reference for Canertinib dihydrochloride, please let us know.

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