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Submit ReviewCannabinol
说明： Cannabinoid receptor agonist; not psychoactive
别名： CBN
化学名： 6,6,9-Trimethyl-3-pentyl-6H-benzo[c]chromen-1-ol
生物活性 for Cannabinol
Cannabinol is a CB2 and CB1 receptor agonist (Ki values are 126 and 211 nM respectively). Inhibits adenylyl cyclase (EC50 values are 120 and 261 nM for CB1 and CB2 receptors respectively) and suppresses immune cell function. Major constituent of cannabis; displays little or no psychotropic activity.
技术数据 for Cannabinol
| 分子量 | 310.43 |
| 公式 | C21H26O2 |
| 储存 | Store at -20°C |
| CAS Number | 521-35-7 |
| PubChem ID | 2543 |
| InChI Key | VBGLYOIFKLUMQG-UHFFFAOYSA-N |
| Smiles | CC1=CC2=C(C(C)(C)OC3=C2C(O)=CC(CCCCC)=C3)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Cannabinol
参考文献 for Cannabinol
参考文献是支持产品生物活性的出版物。
Rhee et al (1997) Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylyl cyclase. J.Med.Chem. 40 3228 PMID: 9379442
Herring et al (1998) Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kB elements by cannabinol, a minimally CNS-active cannabinoid. Biochem.Pharmacol. 55 1013 PMID: 9605425
Zygmunt et al (2002) Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. J.Neurosci. 22 4720 PMID: 12040079
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关键词: Cannabinol, Cannabinol supplier, cannabinoids, CB1, CB2, receptors, agonists, not, psychoactive, CBN, Non-selective, Cannabinoids, 3130, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.