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Cardionogen 1

Cat. No. 4475 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4475 has been discontinued.

说明： Inhibitor of Wnt/β-catenin signaling
化学名： 6-Cyclohexyl-3-(2-furanyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Cardionogen 1

Cardionogen 1 is a wnt signaling modulator. Potently inhibits Wnt/β-catenin-dependent transcription in murine ES cells (EC50 = 23 nM) and zebrafish embryos. Enlarges heart size via cardiomyocyte hyperplasia; induces ES cell cardiac differentiation.

技术数据 for Cardionogen 1

分子量 274.34
公式 C13H14N4OS
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 577696-37-8
PubChem ID 663145
InChI Key SWTUPSNBTSPBIH-UHFFFAOYSA-N
Smiles C12=NN=C(C3=CC=CO3)N1N=C(C4CCCCC4)S2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Cardionogen 1

参考文献是支持产品生物活性的出版物。

Ni et al (2011) Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem.Biol. 18 1658 PMID: 22195568

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Pathways for Cardionogen 1

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.