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SJ 3149

Cat. No. 8141 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective CK1α molecular glue Degrader
Chemical Name: 3-(5-(Benzo[d]isoxazol-3-ylamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SJ 3149

SJ 3149 is a potent and selective CK1α molecular glue Degrader (DC50 = 3.7 nM; Dmax 95% in MOLM-13 cells). SJ 3149 induced near-complete degradation of the CK1α protein (DC50 = 6 nM at 4 hours). Potently inhibits the viability of MOLM-13 cells (IC50 = 13 nM). SJ 3149 displays a broad antiproliferative activity profile on a panel of acute leukemia and solid tumor cell lines. In vivo, SJ 3149 degrades CK1α protein levels in NSG mice transplanted with MOLM-13 cells. SJ 3149 shows 76% orally bioavailability.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Technical Data for SJ 3149

M. Wt 376.37
Formula C20H16N4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 3026986-17-1
PubChem ID 168511381
InChI Key AJUZTJBGJWQZFW-UHFFFAOYSA-N
Smiles O=C1NC(C(CC1)N2C(C3=CC=C(NC4=NOC5=C4C=CC=C5)C=C3C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SJ 3149

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.64 100

Preparing Stock Solutions for SJ 3149

The following data is based on the product molecular weight 376.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.28 mL 26.57 mL
5 mM 0.53 mL 2.66 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

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Reconstitution Calculator

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References for SJ 3149

References are publications that support the biological activity of the product.

Nishiguchi et al (2024) Selective CK1a degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nat.Commun. 15 482 PMID: 38228616

If you know of a relevant reference for SJ 3149, please let us know.

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Citations for SJ 3149

Citations are publications that use Tocris products.

Currently there are no citations for SJ 3149. Do you know of a great paper that uses SJ 3149 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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