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CASIN

Cat. No. 5050 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Cdc42 inhibitor
化学名： 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CASIN

CASIN is a Cdc42 GTPase inhibitor (IC50 = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.

化合物库 for CASIN

CASIN is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for CASIN

分子量 306.4
公式 C20H22N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 425399-05-9
PubChem ID 2882155
InChI Key RXIUMAOXORBRCY-UHFFFAOYSA-N
Smiles OCCNC1C2=C(C(C=C(C4=CC=CC=C4)C=C3)=C3N2)CCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CASIN

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.64 100
ethanol 15.32 50

制备储备液 for CASIN

以下数据基于产品分子量 306.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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产品说明书 for CASIN

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for CASIN

参考文献是支持产品生物活性的出版物。

Florian et al (2012) Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 10 520 PMID: 22560076

Peterson et al (2006) Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem.Biol. 13 443 PMID: 16632257

Li et al (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13 270 PMID: 24012368

If you know of a relevant reference for CASIN, please let us know.

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关键词: CASIN, CASIN supplier, Cdc42, GTPase, inhibitors, inhibits, hematopoietic, stem, cells, HSCs, aged, young, cell, signaling, Stem, Cell, Signaling, Rho, Hematopoietic, Cells, 5050, Tocris Bioscience

2 篇 CASIN 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CASIN 的部分引用包括：

Raymond P et al (2022) Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model. J Virus Erad 8 100307 PMID: 36514715

Cheng et al (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett 585 328 PMID: 21156174

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