CATPB

Cat. No. 5903 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： FFA2 (GPR43) inverse agonist

化学名： (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CATPB

CATPB is a FFA2 inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.

技术数据 for CATPB

分子量	399.79
公式	C₁₉H₁₇ClF₃NO₃
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	1322598-09-3
PubChem ID	53308747
InChI Key	QOSIJVVNNGXEKE-INIZCTEOSA-N
Smiles	OC(C[C@@H](NC(CC1=CC=CC(Cl)=C1)=O)CC2=CC=C(C(F)(F)F)C=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CATPB

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	39.98	100
	ethanol	19.99	50

制备储备液 for CATPB

以下数据基于产品分子量 399.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.5 mL	12.51 mL	25.01 mL
5 mM	0.5 mL	2.5 mL	5 mL
10 mM	0.25 mL	1.25 mL	2.5 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for CATPB

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CATPB

参考文献是支持产品生物活性的出版物。

Park et al (2016) Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 771 1 PMID: 26683635

Sergeev et al (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 291 303 PMID: 26518871

If you know of a relevant reference for CATPB, please let us know.

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Free Fatty Acid Receptors

关键词: CATPB, CATPB supplier, free, fatty, acids, receptors, FFA2, antagonists, inverse, agonists, antagonism, agonism, short, chain, SCFA, Free, Fatty, Acid, Receptors, 5903, Tocris Bioscience

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