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Submit ReviewCB 13
说明： Potent dual CB1/CB2 agonist
化学名： 1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone
纯度： ≥99% (HPLC)
生物活性 for CB 13
CB 13 is a potent, orally active CB1/CB2 receptor agonist with limited brain penetration (EC50 values are 6.1 and 27.9 nM for CB1 and CB2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.
技术数据 for CB 13
| 分子量 | 368.47 |
| 公式 | C26H24O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 432047-72-8 |
| PubChem ID | 9799417 |
| InChI Key | RSUMDJRTAFBISX-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=CC4=C3C=CC=C4)C2=CC=C(OCCCCC)C1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CB 13
参考文献 for CB 13
参考文献是支持产品生物活性的出版物。
Dziadulewicz et al (2007) Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J.Med.Chem. 50 3851 PMID: 17630726
Cluny et al (2010) Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice. J.Pharmacol.Exp.Ther. 334 973 PMID: 20571060
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关键词: CB 13, CB 13 supplier, Potent, dual, CB1/CB2, agonists, cannabinoids, Non-Selective, Receptors, CB13, cb2r, cb1r, Non-selective, Cannabinoids, 2928, Tocris Bioscience
2 篇 CB 13 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CB 13 的部分引用包括：
Alvarez-Fuentes et al (2012) Development and validation of an RP-HPLC method for CB13 evaluation in several PLGA nanoparticle systems. ScientificWorldJournal 2012 737526 PMID: 22792051
Godlewski et al (2010) Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chem Biol 17 1256 PMID: 21095576
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该领域的文献
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.