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CBA

Cat. No. 6724 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective TRPM4 blocker
化学名： 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CBA

CBA is a selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.

化合物库 for CBA

CBA is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CBA

分子量 340.16
公式 C15H11Cl2NO4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 351424-20-9
PubChem ID 2264067
InChI Key CVQCJPCMPGKEDH-UHFFFAOYSA-N
Smiles OC(C1=C(C=C(C=C1)Cl)NC(COC2=C(C=CC=C2)Cl)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CBA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.01 50

制备储备液 for CBA

以下数据基于产品分子量 340.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.88 mL 29.4 mL 58.8 mL
2.5 mM 1.18 mL 5.88 mL 11.76 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
25 mM 0.12 mL 0.59 mL 1.18 mL

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参考文献 for CBA

参考文献是支持产品生物活性的出版物。

Bianchi et al (2018) The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 11 41 PMID: 29996905

Ozhathil et al (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 175 2504 PMID: 29579323

If you know of a relevant reference for CBA, please let us know.

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关键词: CBA, CBA supplier, TRPM4, transient, receptor, potential, melastatin, related, inhibitor, inhibits, blockers, blocks, selective, neuroprotectant, TRPM, 6724, Tocris Bioscience

3 篇 CBA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CBA 的部分引用包括：

O'Malley et al (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations J Neurosci 40 4813 PMID: 32414784

Douglas A et al (2021) TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing. Cell Rep 34 108714 PMID: 33535052

Tamas et al (2021) Electrophysiological Effects of the Transient Receptor Potential Melastatin 4 Channel Inhibitor (4-Chloro-2-(2-chlorophenoxy)acetamido) Benzoic Acid (CBA) in Canine Left Ventricular Cardiomyocytes. Int J Mol Sci 22 PMID: 34502410

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