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CBMR 0083

Cat. No. 7890 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent allosteric FFA1 (GPR40) and 4 (GPR120) agonist
化学名： 1-[3-[[4-Amino-6-[[2-(2,5-dichlorophenyl)ethyl]amino]-1,3,5-triazin-2-yl]methoxy]-5-methylphenyl]-2-pyrrolidinone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CBMR 0083

CBMR 0083 is a potent allosteric free fatty acid receptor 1 (FFA1) and 4 (FFA4) agonist (EC50 values are 1 and 2 nM for FFA1 and FFA4, respectively).

技术数据 for CBMR 0083

分子量 487.39
公式 C23H24Cl2N6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2839486-16-5
PubChem ID 167312323
InChI Key AIIZGUNRDJPXHF-UHFFFAOYSA-N
Smiles O=C1N(CCC1)C2=CC(OCC3=NC(NCCC4=CC(Cl)=CC=C4Cl)=NC(N)=N3)=CC(C)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CBMR 0083

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.74 100

制备储备液 for CBMR 0083

以下数据基于产品分子量 487.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.26 mL 20.52 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
10 mM 0.21 mL 1.03 mL 2.05 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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参考文献 for CBMR 0083

参考文献是支持产品生物活性的出版物。

Lückmann et al (2022) Optimization of first-in-class dual-acting FFAR1/FFAR4 allosteric modulators with novel mode of action. ACS Med.Chem.Lett. 13 1839 PMID: 36518697

If you know of a relevant reference for CBMR 0083, please let us know.

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关键词: CBMR 0083, CBMR 0083 supplier, CBMR0083, free, fatty, acid, receptor, FFA, FFA1, FFA4, GPR40, GPR120, G-protein-coupled, GPCR, allosteric, modulators, agonists, modulator, agonist, Free, Fatty, Acid, Receptors, 7890, Tocris Bioscience

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