CCG 203971

Name: CCG 203971
Brand: Tocris Bioscience
SKU: 5277

Cat. No. 5277 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5277 has been discontinued.

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说明： Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent

化学名： N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for CCG 203971

CCG 203971 is an antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, α-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFβ-stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo. Also suppresses PC-3 cell migration in scratch wound assays (IC₅₀ = 4.2 μM).

技术数据 for CCG 203971

分子量	408.88
公式	C₂₃H₂₁ClN₂O₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1443437-74-8
PubChem ID	71681561
InChI Key	HERLZBNILRVHQN-UHFFFAOYSA-N
Smiles	O=C(N2CCCC(C(NC3=CC=C(Cl)C=C3)=O)C2)C1=CC=CC(C4=CC=CO4)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for CCG 203971

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CCG 203971

参考文献是支持产品生物活性的出版物。

Michel et al (2014) Hope for disease-modifying treatment of systemic sclerosis/scleroderma. J.Pharmacol.Exp.Ther. 350 480 PMID: 25053235

Bell et al (2013) Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg.Med.Chem.Lett. 23 3826 PMID: 23707258

Haak et al (2014) Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J.Pharmacol.Exp.Ther. 349 480 PMID: 24706986

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